Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China.

نویسندگان

  • Guohua Deng
  • Jianzhong Shi
  • Jing Wang
  • Huihui Kong
  • Pengfei Cui
  • Fang Zhang
  • Dan Tan
  • Yasuo Suzuki
  • Liling Liu
  • Yongping Jiang
  • Yuntao Guan
  • Hualan Chen
چکیده

We analyzed eight H10N8 viruses isolated from ducks and chickens in live poultry markets from 2009 to 2013 in China. These viruses showed distinct genetic diversity and formed five genotypes: the four duck isolates formed four different genotypes, whereas the four chicken viruses belong to a single genotype. The viruses bound to both human- and avian-type receptors, and four of the viruses caused 12.7% to 22.5% body weight loss in mice.

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عنوان ژورنال:
  • Journal of virology

دوره 89 12  شماره 

صفحات  -

تاریخ انتشار 2015